How Does Vaping Affect You? Short & Long Term Effects Explained While smoke and vapor may seem similar, smoke from burning delivers a harmful chemical punch due to its chemical reaction. Explore what's inside both and uncover the differences here: https: www.pmi.com our science the difference between cigarette Vapes might be less harmful than traditional cigarettes and might help smokers quit smoking, but that doesn't make them safe especially if you are under 25 years old. Read more here What Is The Difference Between A Vape High And A Smoke High?