How GHK Peptide Works Signaling GHK acts as a switch for skin repair: Interacts with adenosine receptors reduces inflammation Activates MAPK ERK, PI3K Akt, TGF pathways Stimulates fibroblasts & keratinocytes boosts collagen, elastin Integrin Signaling Science CopperGHK increases integrin expression and p63 positivity by keratinocytes Archives of Dermatological Research Springer Nature Link Does GHK Cu Really Work? 40 Years of Research Reviewed