Paracetamol toxicity Deranged Physiology Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. Do you have questions about the use of Tylenol during pregnancy? We spoke with Dr. Janine Hutson, maternal fetal medicine specialist and OBGYN about what the latest research says, what to consider and TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose