One of the biggest concerns Lyme disease patients have when beginning treatment is whether or not they will have a herxing response. In fact, it's one of the most common questions I Managing herxing symptoms while treating Lyme disease? Feeling worse before you feel better? It might be a Herx. Also called a Jarisch Herxheimer reaction, herxing happens when Lyme microbes are killed off and release toxins into your system, sparking a What detox regimens are helpful for herxing symptoms during Lyme disease treatment?