Glutathione is often called the master antioxidant But it's actually regulated by melatonin (PMID: 20868358) Melatonin has been seen to have 10x the antioxidant capacity than glutathione Besides sleep, melatonin also regulates Glutathione: The Master Antioxidant & Its Benefits Modern Endocrine Scheme showing the activation and or deactivation of estrogen Download Scientific Diagram Repression of adenosine triphosphatebinding cassette transporter ABCG2 by estrogen increases intracellular glutathione in brain endothelial cells following ischemic reperfusion injury ScienceDirect
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glutathione and estrogen Sex hormones modulate circulating antioxidant enzymes: Impact of estrogen therapy