Acetaminophen and aspirin toxicity are both high yield, but the injury pattern is very different. Acetaminophen overdose overwhelms glutathione, allowing NAPQI to build up and cause hepatic necrosis. The antidote is N acetylcysteine, which Acetaminophen Hepatotoxicity Clinics in Liver Disease Efficacy of Oral N Acetylcysteine in the Treatment of Acetaminophen Overdose New England Journal of Medicine Acetaminophen Intoxication: A Critical Care Emergency
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