Freckle on Lip: Meaning, Causes and Is It Dangerous? (Labial Melanotic Macule) La Bouche Parfaite This patient has multiple labial melanotic macules. These are essentially freckles of the lips. These most commonly involve the lower lip. This patient had involvement of both the upper and lower lips. Spot the Dot! Growths on the lips are not too common. Clinically, this was consistent with a labial melanotic macule (aka freckle on the lip). These are benign growths which can be A Fast Growing Black Patch on the Upper Front Gum: Malignant Melanoma Springer Nature Link