Ipamorelin Benefits & Side Effects You Must Know Water retention can cause temporary swelling and discomfort, often due to excess salt, hormonal changes, or medical conditions. Here are six easy ways to reduce water retention. If swelling persists or is HRT & Peptide Therapy: Energy, Weight Loss & Balance Peptide side effects no one talks about BPC 157 headaches. TB 500 fatigue. CJC Ipamorelin water retention. Most people quit. But 90% of the time it's the protocol, not the peptide.