Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Did you know acetaminophen lowers glutathione levels? TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose Tylenol & Glutathione What Parents Need to Know! , I get it, many parents are concerned about giving their child Tylenol (acetaminophen) because it can lower glutathione, a crucial antioxidant that