GSH reduces NAPQI, the metabolite responsible for hepatotoxicity in acetaminophen toxicity. Toxic doses increase oxidation into NAPQI, overwhelming glutathione. How does ethanol interfere with acetaminophen metabolism? Image: https: t.co 6EY9dIwLXY Frontiers Exogenous cystine increases susceptibility of drug resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels The effectiveness of compound X is oftentimes dependent on the presence of compounds Y and Z and so on. Endogenous compounds like glutathione get a lot of commercial attention but they do Pt and ZnFe2O4 Nanoparticles Immobilized on Carbon for the Detection of Glutathione ACS Applied Nano Materials