Coffee Enema Erectile Dysfunction: What the Evidence Shows and Practical Considerations Ozonating coffee enemas combines two powerful therapies. The coffee stimulates hepatic glutathione S transferase, upregulating detoxification pathways in the liver. It also increases glutathione While coffee enemas have gained popularity as a wellness trend, it's important to note that there is no scientific evidence to support their effectiveness. Stick to a cup of joe or a Antioxidant effects after coffee enema or oral coffee consumption in healthy Thai male volunteers S Teekachunhatean, N Tosri, C Sangdee, R Wongpoomchai, W Ruangyuttikarn, C Puaninta, S Srichairatanakool, 2012