Oral Malignant Melanoma Oral Cancer Foundation Information and Resources about Oral Head and Neck Cancer Oral Melanotic Macule: Symptoms and Treatment Skinsight Brown spots, especially on the lips, can be alarming to some. In some instances it can indicate rare oral mucosal melanoma, however in this case it was a non cancerous labial melanotic macule. Labial melanotic macule (brown spot on lip) (Stony Brook Case 1) dermatology dermatopathology