Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health 'Don't take Tylenol!', US President Trump has urged pregnant women to avoid Tylenol, citing FDA warnings about a potential increased risk of autism linked to acetaminophen use during pregnancy. Shreya Tylenol's Impact on Glutathione and Liver Damage Tylenol depletes glutathione your liver's most important protective antioxidant. Every dose chips away at it. So instead of taking lower doses every 46 hours, I recommend spacing to 1000mg every 8 hours.