Development of Cagrilintide, a Long Acting Amylin Analogue Journal of Medicinal Chemistry Ever heard of Cagrilintide? Its a peptide thats been making waves for helping with weight loss. , It works by reducing your appetite and helping your body burn fat more efficiently. If youre In the REDEFINE 1 phase 3a trial, semaglutide at a dose of 2.4 mg with cagrilintide at a dose of 2.4 mg led to significant body weight reduction in adults without diabetes and Structural and dynamic features of cagrilintide binding to calcitonin and amylin receptors Nature Communications