Interleukin 4 deficiency protects mice from acetaminophen induced liver injury and inflammation by prevention of glutathione depletion Inflammation Research Springer Nature Link Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem The multiple mechanisms and modes of cell death after acetaminophen overdose Are some people at increased risk of paracetamol induced liver injury? A critical review of the literature European Journal of Clinical Pharmacology Springer Nature Link