Multiscale modelling approach combining a kinetic model of glutathione metabolism with PBPK models of paracetamol and the potential glutathione depletion biomarkers ophthalmic acid and 5 oxoproline in humans and rats Integrative Biology (RSC Full article: Paracetamol: overdose induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro PDF) A review of the evidence concerning hepatic glutathione depletion and susceptibility to liver toxicity after paracetamol overdose Management of Acute Liver Failure (Chapter 6) Case Studies in Adult Intensive Care Medicine
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glutathione depletion paracetamol Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential