Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents ScienceDirect Hemolytic Anemias Part 4: G6PD Deficiency; Pathophysiology,Morphology, clinical features Oxidative Stress in Healthy and Pathological Red Blood Cells In RBCs, NADPH are produced exclusively via HMP shunt by the action of G6PD and are responsible to maintain membrane integrity preventing premature destruction. That is why G6PD deficient RBCs are