Understanding the Role of Carnitine in TPN and IDPN Therapy L Carnitine Benefits, Uses, Dosage, Foods, Side Effects Dr. Axe There's a reason L carnitine keeps showing up in PCOS research Because PCOS is closely tied to insulin resistance, inflammation, and metabolic dysfunctionand L carnitine plays a role in energy metabolism and fat utilization. L carnitine exerts a nutrigenomic effect via direct modulation of nuclear receptor signaling in adipocytes, hepatocytes and SKMC, demonstrating its nutritional impact ScienceDirect