Melanotan 2 10MG Raw Amino Pharmacological Activation of the Melanocortin System Limits Plaque Inflammation and Ameliorates Vascular Dysfunction in Atherosclerotic Mice Arteriosclerosis, Thrombosis, and Vascular Biology Melanotan 2 Revactalabs Melanotan II is a synthetic peptide that mimics the bodys natural melanocortin hormones, primarily activating receptors involved in skin pigmentation, appetite, and central nervous system signaling.