Efficacy and safety of co administered cagrilintide and semaglutide versus semaglutide alone in adults with overweight or obesity with or without type 2 diabetes in Japan and Taiwan (REDEFINE 5): a multicentre, randomised, CagriSema (CagrilintideSemaglutide) in Adults with Overweight or Obesity and Type 2 Diabetes Headlands Research In the REDEFINE 1 phase 3a trial, semaglutide at a dose of 2.4 mg with cagrilintide at a dose of 2.4 mg led to significant body weight reduction in adults without diabetes and Cagrilintide is an amylin analogue that helps regulate appetite. In a randomized trial of over 3400 patients who were overweight or obese and had 1 weight related complication, individuals assigned to a combination
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coadministered cagrilintide and semaglutide in adults with overweight or obesity Cagrilintide–Semaglutide in Adults with Overweight or Obesity and Type 2 Diabetes