The distance between a compound demonstrating efficacy in preclinical research and that compound appearing in a physician's standard toolkit can span a generation. The mechanisms by which NAC addresses oxidative stress, glutamate FAB: Antioxidants in brain linked to improved psychosis treatment Glutathione deficiency in the early postnatal developmental period as a neurodevelopmental animal model of schizophrenia Pharmacological Reports Springer Nature Link Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry Translational Psychiatry