Let's clear something up about MTHFR. You've probably heard it talked about online. Sometimes it's overhyped. Sometimes it's ignored. The truth is somewhere in the middle. MTHFR is a gene that affects MTHFR Gene Mutations Explained: Symptoms, Risks & Testing Guide Inflammatory PCOS and MTHFR: How Methylation, Homocysteine, and Inflammation Affect Hormones Dr Hagmeyer If you have MTHFR , or think you might , this is the most important connection in this series. MTHFR is a gene mutation that impairs methylation. And methylation is the