Parents ask me this all the time: Motrin or Tylenol for fever? Here's my pediatric naturopathic perspective: Motrin treats inflammation, which often drives fever It lasts longer, so fewer doses Figure 1: CMAJ Topical vs Oral Glutathione: Which Is Better for Skin? The parent compounds of acetaminophen (US market in 1955 in the US as Tylenol and other products) were first discovered in 1886 (acetanilide) and 1887 (phenacetin). These were the earliest synthetic fever