How Many Puffs in a Day Is Normal? RELX Vape Knowledge How much nicotine is in a cigarette compared to a vape? Vaping The Guardian Public The amount of nicotine in an e cigarette can vary greatly. Youth may intake nicotine levels that are equivalent to multiple packs of cigarettes. To learn more about the highly addictive Say no to vaping. 10 15 vape puffs are roughly equivalent to one cigarette. We want to encourage and support families to have open and engaging conversations with young people to