How Many Puffs in a Day Is Normal for Vaping? One Puff Of Vape Equals How Many Cigarettes Compared Is The Use Of "one Of The" Correct In The Following Context One Puff Of Vape Equals How Many Cigarettes A Day How Many Puffs of Vape are Equal to a Cigarette? EDGE Vaping The nicotine in 1 vape can equal 50 cigarettes. Depending on the size of the vape and nicotine strength, it can be much higher. Nicotine can harm the developing brain, affecting