Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors. The real danger of Tylenol isn't autism it's liver failure. Acetaminophen, the active ingredient in Tylenol and many cold and flu medications, is one of the leading causes of liver failure Acetaminophen toxicity EMCrit Project