Why Does Glutathione Decline With Age? As we age, our body gradually loses some of its natural protective mechanisms. One of them is glutathione (GSH) a key antioxidant that protects Initial Glutathione Depletion During Short Term Bed Rest: Pinpointing Synthesis and Degradation Checkpoints in the Glutamyl Cycle Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy ACS Omega Frontiers Glutathione: A Samsonian life sustaining small molecule that protects against oxidative stress, ageing and damaging inflammation