Reduction of plasma glutathione in psychosis associated with schizophrenia and bipolar disorder in translational psychiatry Translational Psychiatry Glutathione: Master Antioxidant, Reducing Oxidative Stress, and Detoxification Schematic representation of the proposed pathophysiological cycle Download Scientific Diagram The distance between a compound demonstrating efficacy in preclinical research and that compound appearing in a physician's standard toolkit can span a generation. The mechanisms by which NAC addresses oxidative stress, glutamate